代表性论文: 1. Juan Liu*, Cen Zhang*, Hao Wu, Xiao-Xin Sun, Yanchen Li, Shan Huang, Xuetian Yue, Shou-En Lu, Zhiyuan Shen, Xiaoyang Su, Eileen White, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020, 130:3253-3269. (*: co-first author) (IF:12.772) 2. Juan Liu*, Cen Zhang*, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza, Dajing Xia, Jimin Gao, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Parkin targets HIF-1α for ubiquitination and degradation to inhibit tumor progression. Nat Commun, 2017, 8:1823. (*: co-first author) (IF:12.353) 3. Xuetian Yue, Cen Zhang, Yuhan Zhao, Juan Liu, Alan W. Lin, Victor M. Tan, Justin M. Drake, Lianxin Liu, Michael N. Boateng, Jun Li, Zhaohui Feng, Wenwei Hu. Gain-of-function mutant p53 activates Proof Only small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev, 2017, 31: 1641-1654.(IF:9.462) 4. Cen Zhang*, Juan Liu*, Grace Huang, Yuhan Zhao, Xuetian Yue, Hao Wu, Jun Li, Junlan Zhu, Zhiyuan Shen, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev, 2016, 30:1956-70. (*: co-first author) (IF:9.462) 5. Cen Zhang*, Juan Liu*, Yuhan Zhao, Xuetian Yue, Yu Zhu, Xiaolong Wang, Hao Wu, Felix Blanco, Shaohua Li, Gyan Bhanot, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife, 2016, 5:e10727. (*: co-first author) (IF:7.616) 6. Xuetian Yue, Yuhan Zhao, Cen Zhang, Jun Li, Zhen Liu, Juan Liu, Wenwei Hu. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. Oncotarget, 2016, 7:3777-3790.(IF:5.168) 7. Yuhan Zhao, Cen Zhang, Xuetian Yue, Xiaoyan Li, Juan Liu, Haiyang Yu, VA Belyi, Qifeng Yang, Zhaohui Feng, Wenwei Hu. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. Cell Death Differ, 2014, 22:1824-1836. (IF:8.000) 8. Juan Liu*, Cen Zhang*, Xiaolong Wang, P Ly, V Belyi, Zijun Y Xu-Monette, Ken H Young, Wenwei Hu, Zhaohui Feng. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ, 2014, 21:1792-1804. (*: co-first author) (IF:8.000) 9. Cen Zhang, Juan Liu, Yingjian Liang, Rui Wu, Yuhan Zhao, Xuehui Hong, Meihua Lin , Haiyang Yu, Lianxin Liu, Arnold J. Levine, Wenwei Hu, Zhaohui Feng. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nat. Commun., 2013, 4:2935.(IF:12.353) 10. Zhaohui Feng, Lianxin Liu, Cen Zhang, Tongsen Zheng, Jiabei Wang, Meihua Lin, Yuhan Zhao, Xiaowen Wang, Arnold J. Levined and Wenwei Hu. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 2012, 109: 7013-7018. (IF:9.504) 11. Cen Zhang, Meihua Lin, Rui Wu, Xiaowen Wang, Bo Yang, Arnold J. Levine, Wenwei Hu and Zhaohui Feng. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.Proc Natl Acad Sci U S A, 2011, 108:16259-64.(IF:9.504) 12. Wenwei Hu, Chang S. Chan, Rui Wu, Cen Zhang, Yvonne Sun, Jun S. Song, Laura H. Tang, Arnold J. Levine and Zhaohui Feng. Negative Regulation of Tumor Suppressor p53 by microRNA miR-504. Mol Cell, 2010, 38:689-699.(IF:14.248) 13. Wenwei Hu, Cen Zhang, Rui Wu, Yvonne Sun, Arnold J. Levine and Zhaohui Feng. Glutaminase 2 is a novel p53 target gene regulating energy metabolism. Proc. Natl. Acad. Sci. USA, 2010, 107:7455-7460.(IF:9.504) |