部分代表性论文:(*为通讯作者) 仅列第一作者/通讯作者论文(Only first/corresponding authorship): 1. Zhou, Y.; Song, M.; Xie, D.; Yan, S.; Yu, S.; Xie, S.; Cai, M.; Li, H.; Shang, L.; Jiang, L.; Yuan, C.; Huang, M.*; Li, J.*; Xu, P.*, Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase Receptor. J Med Chem 2023, doi: 10.1021/acs.jmedchem.2c01663 2. Xiao, H. P.; Hao, Y. S.; Li, X. X.*; Xu, P.*; Huang, M. D.; Zheng, S. T.*, A Water-Soluble Antimony-Rich Polyoxometalate with Broad-Spectrum Antitumor Activities. Angew Chem Int Edit 2022, 61 (41). 3. Lin, H. L.; Xu, P.*; Huang, M. D.*, Structure-based molecular insights into matrix metalloproteinase inhibitors in cancer treatments. Future Med Chem 2022, 14 (1), 35-51. 4. Chen, J. Y.; Jing, Q.; Xu, Y. J.; Lin, Y. X.; Mai, Y. H.; Chen, L. Y.; Wang, G. D.; Chen, Z.; Deng, L. N.; Chen, J. C.; Yuan, C.; Jiang, L. G.; Xu, P.*; Huang, M. D.*, Functionalized zinc oxide microparticles for improving the antimicrobial effects of skin-care products and wound-care medicines. Biomaterials Advances 2022, 135. 5. Song, M. R.; Liu, G.; Liu, Y. C.; Cheng, Z. W.; Lin, H. L.; Liu, J. Y.; Wu, Z. S.; Xue, J. P.; Hong, W. J.; Huang, M. D.; Li, J. Y.*; Xu, P.*, Using porphyrins as albumin-binding molecules to enhance antitumor efficacies and reduce systemic toxicities of antimicrobial peptides. European Journal of Medicinal Chemistry 2021, 217. 6. Cheng, Y.; Liu, Y. R.; Chen, D.; Zhou, Y.; Yu, S. J.; Lin, H. J.; Liao, C. K.; Lin, H. L.; Xu, P.*; Huang, M. D.*, Dual effects of quercetin on protein digestion and absorption in the digestive tract. Food Chemistry 2021, 358. 7. Xu, P.; Huang, M. D., Small Peptides as Modulators of Serine Proteases. Curr Med Chem 2020, 27 (22), 3686-3705. 8. Wang, D.; Yang, Y. S.; Wang, Y.; Proulle, V.; Andreasen, P. A.; Hong, W. J.; Chen, Z.*; Huang, M.* D.; Xu, P.*, Embelin ameliorated sepsis-induced disseminated intravascular coagulation intensities by simultaneously suppressing inflammation and thrombosis. Biomed Pharmacother 2020, 130. 9. Wang, D.; Liu, W. Z.; Wang, L.; Wang, Y.; Liao, C. K.; Chen, J. C.; Hu, P.; Hong, W. J.; Huang, M. D.; Chen, Z.*; Xu, P.*, Suppression of cancer proliferation and metastasis by a versatile nanomedicine integrating photodynamic therapy, photothermal therapy, and enzyme inhibition. Acta Biomaterialia 2020, 113, 541-553. 10. Lin, H. L.; Xu, L. N.; Yu, S. J.; Hong, W. J.; Huang, M. D.; Xu, P.*, Therapeutics targeting the fibrinolytic system. Exp Mol Med 2020, 52 (3), 367-379. 11. Hu, P.; Shang, L.; Chen, J. C.; Chen, X. Z.; Chen, C.; Hong, W. J.; Huang, M. D.; Xu, P.*; Chen, Z.*, A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment. J Mater Chem B 2020, 8 (3), 504-514. 12. Zuo, K.; Qi, Y. Y.; Yuan, C.; Jiang, L. G.; Xu, P.*; Hu, J. P.*; Huang, M. D.*; Li, J. Y.*, Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors. Cancer Metast Rev 2019, 38 (3), 507-524. 13. Yan, S. F.; Huang, Q. Q.; Chen, J. C.; Song, X. R.; Chen, Z.; Huang, M. D.; Xu, P.*; Zhang, J. C.*, Tumor-targeting photodynamic therapy based on folate-modified polydopamine nanoparticles. Int J Nanomed 2019, 14, 6799-6812. 14. Wang, D.; Yang, Y. S.; Jiang, L. G.; Wang, Y.; Li, J. Y.; Andreasen, P. A.; Chen, Z.; Huang, M. D.*; Xu, P.*, Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. Journal of Medicinal Chemistry 2019, 62 (4), 2172-2183. 15. Jia, Y. H.; Li, J. Y.*; Chen, J. C.; Hu, P.; Jiang, L. G.; Chen, X. Y.; Huang, M. D.; Chen, Z.*; Xu, P.*, Smart Photosensitizer: Tumor-Triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. Acs Appl Mater Inter 2018, 10 (18), 15369-15380. 16. Xu, P.; Jia, Y. H.; Yang, Y. S.; Chen, J. C.; Hu, P.; Chen, Z.*; Huang, M. D.*, Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone Receptors. Journal of Medicinal Chemistry 2017, 60 (20), 8667-8672. 17. Xu, P.; Andreasen, P. A.; Huang, M. D.*, Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors. Int J Biol Sci 2017, 13 (10), 1222-1233. 18. Xu, P.; Xu, M. M.; Jiang, L. G.; Yang, Q. L.; Luo, Z. P.; Dauter, Z.; Huang, M. D.; Andreasent, P. A.*, Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. Journal of Medicinal Chemistry 2015, 58 (22), 8868-8876. 19. Zhao, B. Y.#; Xu, P.#; Jiang, L. G.; Paaske, B.; Kromann-Hansen, T.; Jensen, J. K.; Sorensen, H. P.; Liu, Z.; Nielsen, J. T.; Christensen, A.*; Hosseini, M.; Sorensen, K. K.; Nielsen, N. C.; Jensen, K. J.; Huang, M. D.; Andreasen, P. A., A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity by Increasing Peptide Flexibility. Plos One 2014, 9 (12). 20. Xu, P.; Chen, J. C.; Chen, Z.*; Zhou, S. Y.; Hu, P.; Chen, X. Y.; Huang, M. D.*, Receptor-Targeting Phthalocyanine Photosensitizer for Improving Antitumor Photocytotoxicity. Plos One 2012, 7 (5).
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