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College of Biological Science and Engineering

关怡

发布日期:2023-04-10 发布者:

姓名:关怡

性别:女

职称:副教授/博士生导师

学历:理学博士

QQ:346138739

电子邮箱:gy@fzu.edu.cn

研究方向:真菌基因功能、微生物抗生素耐药性、微生物酶学及其应用

教育工作经历:

1. 2019.6-至今  福州大学,副教授

2. 2016.8-2019.6 福州大学,讲师

3. 2011.8-2016.6 浙江大学,微生物学,博士

4. 2007.9-2011.6 福建农林大学,生物技术,学士

承担课程:

微生物学、基因工程、微生物工程、微生物学实验、细胞生物学实验、综合实验课、酶工程及其应用(硕士研究生课程)

科研简介:

结合基因编辑、异源表达等分子生物学手段及微生物代谢组、转录组等组学分析技术,开展昆虫病原真菌基因功能、植物病原细菌抗生素耐药性等相关方向的研究

社会兼职:

1.中国生物化学与分子生物学会农业生物化学与分子生物学分会,青年委员

2.福建省细胞生物学与转化医学学会,理事会理事

科研项目:

1. 国家自然科学基金面上项目:多组学联合解析BbRho4调控球孢白僵菌生长及抗氧化力的分子机制,2020.01-2024.12,主持

2. 国家自然科学基金青年项目:Rho家族GTPase对球孢白僵菌极性生长及抗氧化力的作用研究,2018.01-2020.12,主持

3. 福建省自然科学基金青年创新项目:小GTP酶Rho4对球孢白僵菌生长、抗逆的作用研究,2018.04-2021.03,主持

4. 福建省教育厅一般项目:柑橘类水果皮中产果胶酶菌株的筛选及鉴定,2017.07-2020.06,主持

5. 福州市科技局科技计划项目:果胶酶的发酵生产及其在动物饲料中的应用,2017.03-2019.03,主持

6. 福州大学贵重仪器设备开放测试基金:代谢组学在水稻黄单胞菌抗药性形成机制中研究中的应用,2019.01-2019.12,主持

近年代表性论文:(*为通讯作者)

Guan, Y.*, Lin, M., Shen, P. & Zou, Z. (2023) Alanine-mediated P cycle boosting enhances the killing efficiency of kasugamycin on antibiotic-resistant Xanthomonas oryzae, Frontiers in Microbiology. 14:1160702

Zou, Z., Lin, M., Shen, P. & Guan, Y*. (2023) Alanine-Dependent TCA Cycle Promotion Restores the Zhongshengmycin-Susceptibility in Xanthomonas oryzae, International Journal of Molecular Sciences. 24.

Guan, Y.*, Wang, D., Lin, X., Li, X., Lv, C., Wang, D. & Zhang, L*. (2022) Unveiling a Novel Role of Cdc42 in Pyruvate Metabolism Pathway to Mediate Insecticidal Activity of Beauveria bassiana, Journal of fungi. 8.

Guan, Y.*, Shen, P., Lin, M. & Ye, X*. (2022) Exogenous Alanine Reverses the Bacterial Resistance to Zhongshengmycin with the Promotion of the P Cycle in Xanthomonas oryzae, Antibiotics. 11.

Zhang, L.*, Qiu, T., Huang, Z., Ye, X. & Guan, Y.* (2021) Transcriptomic analysis of Sur7-mediated response of Beauveria bassiana to different nutritional conditions, FEMS microbiology letters. 368.

Wang, Q., Lin, M., Shen, P. & Guan, Y.* (2021) Elevation of Fatty Acid Biosynthesis Metabolism Contributes to Zhongshengmycin Resistance in Xanthomonas oryzae, Antibiotics. 10.

Guan, Y., Wang, Q., Lv, C., Wang, D. & Ye, X.* (2021) Fermentation time-dependent pectinase activity is associated with metabolomics variation in Bacillus licheniformis DY2, Process Biochemistry. 101, 147-155.

Guan, Y., Wang, D., Lv, C., Zhang, Y., Gelbic, I.* & Ye, X.* (2020) Archives of microbiology: screening of pectinase-producing bacteria from citrus peel and characterization of a recombinant pectate lyase with applied potential, Archives of microbiology. 202, 1005-1013.

Du, X., Wang, D., Yin, D., Guan, Y.* & Ye, X.* (2019) Exogenous Glucose Promotes Growth and Pectinase Activity of Bacillus licheniformis DY2 Through Frustrating the TCA Cycle, Biotechnology and Bioprocess Engineering. 24, 942-953.

Guan, Y.*, Yin, D., Du, X. & Ye, X.* (2018) Metabolomics approach used for understanding temperature-related pectinase activity in Bacillus licheniformis DY2, FEMS microbiology letters. 365.

Guan, Y.*, Yin, D., Du, X. & Ye, X.* (2018) Functional metabolomics approach reveals the reduced biosynthesis of fatty acids and TCA cycle is required for pectinase activity in Bacillus licheniformis, J Ind Microbiol Biotechnol. 45, 951-960.

获奖情况:

1. 2019.6 福州大学优秀本科生毕业论文指导教师

2. 2018.12 福州大学“三下乡”社会实践先进工作者

其他: