科研简介: 主要研究领域为: (1)无细胞转录翻译系统 Cell-free transcription-translation systems; (2)基因回路与生物探测器 Genetic circuits and biosensors; (3)蛋白质高通量表达和筛选 High-throughput screening of proteins/enzymes. Our group mainly focuses on prototyping and building novel biological circuits in both cell-free systems and cells, and using synthetic biology tools to advance the discovery of new enzymes. We are interested in utilizing cell-free systems to assist the research in synthetic biology by performing fast prototyping on biological parts and modules, with the goals of building novel biological circuits and metabolic pathways to tackle various problems. 欢迎对合成生物学感兴趣的硕士生、本科生加入课题组! |
代表性论著: 1. Guo, S., M. Wang, W. Xu, et al., Rapid screening of glycosyltransferases in plants using a linear DNA expression template based cell-free transcription-translation system. Phytochemistry, 2022. 193: p. 113007. 2. Wei, Z., X. Shi, R. Lian, et al., Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering. Antibiotics (Basel), 2019. 8(4). 3. Guo, S. and R.M. Murray, Construction of Incoherent Feedforward Loop Circuits in a Cell-Free System and in Cells. ACS Synth Biol, 2019. 8(3): p. 606-610. 在研项目: 1. 国家自然科学基金青年科学基金项目:利用无细胞转录翻译系统和生物回路实现植物糖基转移酶的高通量研究(2020年-2023年) 2. 福建省科学技术厅自然科学基金项目:利用无细胞转录翻译系统快速筛选植物糖基转移酶的研究(2020年-2023年) |